Controlled laser-induced cavitation for cargo release
Gašper Kokot
Complex Matter Department, Jožef Stefan Institute
Abstract:
Encapsulation of a drug in order to release it after it reaches the affected body site is the goal of targeted drug delivery. Many mechanisms have been proposed as triggers for the drug release from chemical, near infra red (NIR) light to electric field, yet none of them was able to provide temporal alongside spatial control. We will show a low power NIR light regime where we can induce local cavitation bubble by illuminating an optically opaque microparticle with an optical tweezers pulse. When the particle is attached to the membrane of a giant unilamellar vesicle (GUV) the laser induced cavitation damages the membrane and we observe a release of the interior solution. We have positional control over the optical tweezers allowing us to specifically target the GUVs. Moreover, the method does not damage cells, which is a desirable outcome for targeted drug delivery.
The seminar will take place via Zoom. The details for connecting to the meeting can be found below:
Join Zoom Meeting
https://zoom.us/j/97046995988?pwd=NDBKVDFyVzgzb3NWbk5Ra0NGbkEzQT09
Meeting ID: 970 4699 5988
Passcode: 851027
Link to previous seminars:
Calendar of upcoming seminars
| Date | Name | Topic of the seminar |
|---|