We focus on investigations of guanosine derivatives. They have the remarkable property of being able to spontaneously self-assemble into various nanostructures, which are candidates for applications in nanotechnology. We study self-assembly in solutions, thin films on water surface and thin films on solid substrates.

Dynamic light scattering is used to investigate self-assembly of guanosine derivatives in solutions and the thin films are prepared by Langmuir-Blodgett techniques. Atomic force microscopy (AFM) gives information on the deposition of G-quadruplexes and the quadruplexes can be identified by their height profile.

Selected references:

LIČEN, Matjaž, MASIERO, Stefano, DREVENŠEK OLENIK, Irena. Photoisomerizable guanosine derivative as a probe for DNA basepairing in Langmuir monolayers. Langmuir, ISSN 0743-7463, 2019, vol. 35, iss. 20, str. 6550-6561, ilustr., doi: 10.1021/acs.langmuir.9b00429.

ČOGA, Lucija, SPINDLER, Lea, MASIERO, Stefano, DREVENŠEK OLENIK, Irena. Molecular recognition of a lipophilic guanosine derivative in Langmuir films at the air-water interface. Biochimica et biophysica acta (G). General subjects, ISSN 0304-4165. [Print ed.], 2017, vol. 1861, iss. 5, part B, str. 1463-1470, ilustr., doi: 10.1016/j.bbagen.2016.11.038.

TROHA, Tinkara, DREVENŠEK OLENIK, Irena, WEBBA DA SILVA, Mateus, SPINDLER, Lea. Surface-adsorbed long G-quadruplex nanowires formed by G:C linkages. Langmuir, ISSN 0743-7463, 2016, vol. 32, iss. 28, str. 7056-7063, ilustr., doi: 10.1021/acs.langmuir.6b01222.

ČOGA, Lucija, MASIERO, Stefano, DREVENŠEK OLENIK, Irena. Ion-specific self-assembly of a lipophilic guanosine derivative in thin surface films. Langmuir, ISSN 0743-7463, 2015, vol. 31, iss. 17, str. 4837-4843, ilustr. http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.5b00768, doi: 10.1021/acs.langmuir.5b00768.